A woman in Brazil who received a womb transplanted from a deceased donor has given birth to a baby girl in the first successful case of its kind, doctors reported.
The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins, as well as linking arteries, ligaments and vaginal canals.
It comes after 10 previously known cases of uterus transplants from deceased donors – in the United States, the Czech Republic and Turkey – failed to produce a live birth.
The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams (nearly 6 lbs), the case study said.
Dani Ejzenberg, a doctor at Brazil’s Sao Paulo University hospital who led the research, said the transplant – carried out in September 2016 when the recipient was 32 – shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.
The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.
“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” Ejzenberg said in a statement about the results.
She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.
The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.
Experts estimate that infertility affects around 10 to 15 percent of couples of reproductive age worldwide. Of this group, around one in 500 women have uterine problems.
Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.
In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Kuster-Hauser syndrome. The donor was 45 and died of a stroke.
We women juggle multiple roles and handle a zillion responsibilities, both at work and at home. Nothing motivates a multitasking woman as much as confidence. It is that secret tool in her arsenal that gets her going—helping her achieve her full potential in every aspect of her day-to-day life and helping her face whatever life throws at her.
For most women, good skin is high up on the list of confidence boosters. It plays an important part in how a woman views herself, how she behaves in her daily environment, and how she tackles challenges and other factors that affect her. This is often referred to as skin confidence. Skin confidence comes from good skin health—when your skin is well-attended-to and in its optimal health, it boosts your self-esteem and makes it easier for you to focus on the many other tasks you need to accomplish.
Hot Indian summers and pollution can dampen your skin confidence; they are quite harsh on the skin and create problems for it. Cricketer Smriti Mandhana became quite the internet sensation during the ICC Women’s World Cup 2017. The whole country not only fell in love with this 21-year-old’s game but also her natural beauty.
Just like any young woman, Mandhana too worries about her skin especially because she spends so much time outdoors in the sun while playing or practising, and is also affected by pollution while on the move. Luckily, she’s found a perfect sun and protection shield—the Vaseline Sun and Pollution Protection body lotion. It comes with SPF 24 PA++ which defends the skin from the harsh rays of the sun and Pollution Protection Formula, which protects it from harmful pollutants. This lotion helps Mandhana not only protect her skin but also helps her restore its natural radiance, so that she can focus on bigger things, like say, winning the World Cup for the country.
It may seem like a small thing but on a good skin day, you will feel your best. You’ll feel a little more confident than usual. And, if you have skin confidence, it’s a guaranteed that you will feel like you can get more out of life. In simpler terms, you want to step out, meet people and make connections, take on the world with confidence and have fun while you’re at it.
The traditional diet of people in Mediterranean countries has been linked to numerous health benefits and has been shown to cut the risk of obesity. Although popular elsewhere, this healthy eating pattern is relatively new to the USA. New research being presented at this year’s European Congress on Obesity (ECO) in Vienna, Austria (23-26 May) uses geospatial techniques to identify which US states have the greatest adherence to this Mediterranean-style of eating. Western and northeastern coastal areas of the USA including California, New Jersey, New York City, and Massachusetts lead the nation following this healthier eating pattern, while residents of the South and East North Central states such as Arkansas, Louisiana, Alabama, and Michigan are least likely to adopt the Mediterranean-style diet.
The Mediterranean diet is rich in fruits, vegetables, nuts, whole grains, and olive oil. It’s low in red meat and other saturated fats, and it contains few processed foods or refined sugars. This eating pattern has well known health benefits, including reduced mortality and lower risk of chronic conditions such as cancer, diabetes, and heart disease.
Current dietary guidelines reveal that around three-quarters of Americans do not eat enough vegetables, fruit, and dairy, and most exceed the recommendations for added sugars, saturated fats, and salt. The estimated annual healthcare costs of obesity-related illness are a staggering US$190 billion or a fifth of annual medical spending in the USA. Increased adoption of the Mediterranean diet could help reverse this public health crisis, but little is known about the popularity of this dietary patternacross the USA.
In this study, researchers led by Professor Meifang Chen from California State University, Los Angeles investigated adherence to the Mediterranean diet among almost 21,000 adults (aged 45 or older) from 48 contiguous states and Washington DC taking part in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. The study is tracking stroke incidence and mortality from an ethnically and demographically diverse sample of the US population.
Participants completed detailed food questionnaires at the start of the study, and the researchers calculated a Mediterranean diet adherence (MD) score for each participant based on the types of food they ate—ranging from 0-9, with a higher score showing greater adherence. The researchers used geospatial and hot spot analysis to see the geographical distribution and pattern of Mediterranean diet adoption across study areas. Modelling was also used to identify factors associated with high adherence.
The average MD score was 4.36, and almost half (46.5% of participants) closely followed the Mediterranean Diet. The researchers found that higher Mediterranean diet adherence clusters were mainly located in the western and northeastern coastal areas including Californian, Pennsylvania, New Jersey, New York City, Connecticut, and Massachusetts; whereas lower adherence clusters were largely seen in South and East North Central regions such as Arkansas, Louisiana, Alabama, Georgia, North Carolina, Michigan and the northern area of Indiana (see map).
Further analyses showed that, irrespective of geographical location, people who live in socioeconomically disadvantaged, rural, minority neighborhoods with smaller populations are least likely to follow this ‘healthier’ diet pattern. Being older, black, not a current smoker, having a college degree and above, an annual household income of US$75,000 or more, exercising at least four times a week, and watching less than 4 hour of TV a day were each linked with a higher likelihood of eating the Mediterranean-style diet.
The authors conclude: “Given the skyrocketing obesity rates in the USA over the past few decades, identifying and promoting obesity-modifying dietary approaches is a top priority. Our study identifies and characterises locations and at-risk populations across the USA where Mediterranean diet promoting interventions and policies might have the greatest effect in combating the obesity.”
The authors note some limitations, including that the MD score was calculated based on self-reported dietary intake data, which might not accurately represent participants’ food consumption. For instance, inaccurate recall of food intake, or a tendency towards social desirability resulting in individuals over-reporting healthy food intake, and underreporting unhealthy food intake can’t be ruled out. They also note that dietary intake data was only assessed once at the start of the study, so the stability of the dietary pattern is unknown. Lastly, the study represented only two racial groups (non-Hispanic white and black) and mid- to old-age populations, so the findings might not be generalisable to younger generations and other racial groups.
Microchip maker Intel Corp responded to a news report that it is considering a possible bid for Broadcom Ltd by saying that it is focused on integrating previous acquisitions, raising doubt over the idea.
The Wall Street Journal reported on Friday that Intel’s competitive concern about Broadcom’s attempt to buy mobile chip rival Qualcomm had led it to consider a range of acquisitions in response, including a bid for Broadcom.
In response to an inquiry about the Journal’s report, Intel said it does not comment on “rumours or speculation” related to mergers and acquisitions but that it is focused on its previous acquisitions.
“We have made important acquisitions over the past 30 months – including Mobileye and Altera – and our focus is on integrating those acquisitions and making them successful for our customers and shareholders,” Intel said in a statement to Reuters. Intel acquired autonomous vehicle technology firm Mobileye last year and acquired programmable chip maker Altera in late 2015.
Broadcom did not immediately respond to a request for comment.
Shares of Broadcom rose 3.6 percent to $262.93 in after hours trade on Friday. Qualcomm and Intel each fell less than 1 percent, to $62.87 and $51.84, respectively.
Singapore-based Broadcom’s $117 billion bid for Qualcomm faces concerns by U.S. regulators worried about potential Chinese influence on the company and U.S. ability to influence the creation of the next generation of mobile networks, called 5G.
Qualcomm has sought assurances from Broadcom over potential antitrust issues.
Intel is mostly known for making chips that are the brains of personal computers and data centres, though it has made progress gaining smartphone manufacturing customers such as Apple.
If Broadcom buys Qualcomm, Intel would face a much bigger competitor, nearly equal to itself in market heft.
Broadcom and Qualcomm are worth close to $100 billion each and a combination would be the biggest tech deal ever. An Intel deal would be significantly bigger, since its market capitalization alone is nearly $240 billion.
The Journal reported that Intel had been considering a Broadcom bid since late last year and was working with advisers, although the newspaper said one of its sources described a bid as unlikely given the complexity of the combination.
Still, antitrust consultant Linley Gwennap said Intel likely could convince regulators to allow it to take over Broadcom, despite the size, since the companies largely make different types of microchips.
VLSI Research chief Dan Hutcheson agreed. “There’s product overlap, but it’s really inconsequential,” he said.
Microsoft’s big promise with Windows 10 has always been a version of Windows that will run across multiple devices. While we’ve seen Windows 10 power devices like the HoloLens, an Xbox One console, or even phone hardware, Microsoft has often created separate interfaces and software to sit on top of the underlying core of Windows. That’s meant the Xbox home screen looks different to the Xbox app on Windows 10, and that the mobile version of Windows 10 has always felt like a truly separate version of Windows. Microsoft’s future vision now involves clever modes for clever hardware.
Sources familiar with Microsoft’s Windows plans tell The Verge that the software giant is developing Windows to adapt and run on a single device with many modes. We’ve seen early examples of this with Microsoft’s Continuum work for both Windows 10 tablets and phones, allowing regular laptops to transform into tablets and phones to morph into PCs. These existing modes haven’t always included the features you’d expect, nor the same user interface or software.
Microsoft is now creating a Composable Shell (C-Shell) for its own developers as well as creators of Universal Windows Apps to make use of. Windows Central first reported on C-Shell last year, and it’s essentially a more modular version of the existing Windows Shell that powers the Start menu and notification center. At the moment, Microsoft builds and maintains multiple versions of the Start menu for different devices, but the vision with C-Shell is to create a single Start menu that automatically spans across different modes and different devices.
This idea of modes is particularly relevant when you consider Microsoft’s future Surface plans. Microsoft has been widely rumored to be working on a secret Surface notepad device, with foldable dual displays. Patents have shown off hardware that looks very similar to Microsoft’s Courier concept of a digital notepad, with a clever hinge powering the two displays. The patents also show Microsoft’s potential device adapts to become more than a notepad or a tablet, and into a laptop-like form factor. Coupled with the ability to connect to a larger display, you could imagine this device, codenamed Andromeda, adapting to many different modes. Microsoft CEO Satya Nadella has also previously promised that Microsoft’s future “phones” won’t look like phones at all.
Microsoft’s Windows vision includes the idea of a gaming mode for playing games with an Xbox controller, a quiet mode with a desktop for productivity, and a kids mode that acts more like a tablet with a simple interface. These different modes are designed to scale across a variety of hardware, including hardware that has not yet been released yet. The idea is that this C-Shell could eventually replace the existing legacy desktop in Windows, and be the main shell across all devices. That all depends on C-Shell being truly adaptable enough, but Microsoft has codenamed this desktop effort Polaris.
We’ve seen some early examples of how C-Shell will influence Microsoft’s adaptable user interfaces for Windows, but we haven’t seen any new devices to really show why this project matters to Microsoft. That’s about to change in the coming months. Microsoft is planning to unveil its Surface Hub 2 in the first half of 2018, and it will be Microsoft’s first hardware to showcase C-Shell. Microsoft is also expected to unveil its mystery Andromeda Surface device this year, and it will set the stage for similar hardware from PC makers with adaptive modes.
Microsoft’s existing Surface Hub is already powered by Windows 10, running its own custom shell. The second-generation Surface Hub will give us an early look at how Microsoft further adapts Windows 10 for different screen sizes, scenarios, and hardware. The changes will be subtle at first, but Microsoft’s vision should lead to single devices that can adapt (just like Surface) to form factors and hardware that doesn’t even exist today.
Gif. Jif. No matter your pronunciation preference, it’s easy to create that wordusing a variety of apps and services. Since I started working at Lifehacker, I’ve found that it’s sometimes easier to show, not tell, in the form of a little animated image that demonstrates some key feature or setting. Consequently, I’ve started making a lot of GIFs, and here’s the app I use to do it on Windows.
The app ScreenToGif is GreatToHave for making GIFs
I don’t recall where I stumbled across ScreenToGif, but I love this app. When you first pull it up, you’re presented with a simple menu that shows off the app’s four key functions: Recording your screen and turning that into a GIF, transforming the silly faces you make into your webcam into a GIF, launching a digital whiteboard and turning your scribbles into a GIF, and a general editor you can use to take existing files (like MP4 videos) and make them GIFs.
For the screen-recording bit, click on the big red Recorder icon and a fun little window overlay will appear—a picture frame of-sorts that you resize around the area you want to capture. Set your desired frames-per-second and hit F7 to start your recording and F8 to stop.
As soon as you stop recording, ScreenToGif launches its editor and automatically loads whatever it is you just captured. The GIF editor is kind of like a simplified video editor—since a GIF and a video both create the appearance of motion in similar (but identical) ways.
You can go through your potential GIF frame by frame and trim or delete that which you don’t want in the final product. You can also add or reduce the amount of time between each frame (to shorten or lengthen the speed of your GIF), move frames around, add transitions and slides, and pepper your GIF with witty text captions or other overlay elements.
Disaster Manual: Surviving Nuclear Fallout
When you’re ready to create your GIF (File >> Save As), you can encode it using a variety of options (including FFMPEG and Gifski). Each will give you a different combination of quality and file size, so be sure to try a few to figure out which is best for your GIF-making needs. Here are a few I created using the 1.0, 2.0, and Gifski encoders, respectively:
Do you have a Windows app (paid or free) that you absolutely love? Tell us about it:email@example.com.